When comedian Kathy Griffin won an Emmy award for her reality TV show, she couldn’t help but offend someone — this time it was the Catholics.

“A lot of people come up here and thank Jesus for this award,” but “no one had less to do with this award than Jesus,” she said during her acceptance speech at the September ceremony.

While the Catholic League condemned her remarks, Griffin has gotten plenty of publicity out of it.

“Isn’t it funny that everyone has gotten so high and mighty that they’re worried about my little Jesus joke,” Griffin told the Sun-Sentinel (Fort Lauderdale, Fla.). “But it paid off big time. I was in every magazine and all over the news.

“You have to wonder whatever happened to humor in this country. A lot of it is probably just garden-variety sexism. They’re not used to hearing stuff like that from a woman. But I’m cracking up because, at the age of 47, I’m ‘the envelope-pushing comedian Kathy Griffin,’” she said.

Griffin takes the stage for a May 10 show at the Silver Legacy Resort Casino.

“I am not for children. I am not for the faint of heart,” she said of her act to the Courier-Journal (Louisville, Ky.). “If you mind cussing, don’t come. It’s an evening of swearing, negativity and fun. That’s a good recipe, right?”

Her stand-up routine isn’t based on jokes, but more about mocking celebrities and herself.

“That’s really my thing,” she told the Commercial Appeal (Memphis, Tenn.) of her trash talking. “My act is story-oriented. I’m not really a joke-teller, and audiences know my celebrity stories are true, my stories about all the celebrities we’re obsessed with — Tom Cruise, Lindsay Lohan, Oprah ...

“The thing is, I don’t like hanging out with famous people — that’s not fun for me. I really can’t do my job if I’m friendly with these people,” she said.

Griffin began her comedy career at Los Angeles’ Groundlings Theater, where she performed for seven years, according to her biography. In 1994, she pursued a full-time career as a stand-up comedian, which started with appearances at various Los Angeles venues.

She then created and starred in “Hot Cup of Talk,” an alternative stand-up show performed at the Groundlings Theater. The show featured comics such as Janeane Garofalo, Julia Sweeney, Margaret Cho, Dana Gould and Andy Dick.

In 1996, Griffin made a name for herself as Brooke Shields’ acerbic colleague on the NBC sitcom “Suddenly Susan.” When the show was canceled in 2000, reality TV shows kept her profile afloat — she starred in 2001’s “Kathy’s So-Called Reality,” participated in and won 2003’s “Celebrity Mole” and hosted 2003’s “Average Joe.”

Her biggest reality TV success is “Kathy Griffin: My Life on the D-List,” which returns for a fourth season in June on Bravo. The series follows Griffin around and shows her at her self-deprecating best and worst.

With her success on the D-list, Griffin told the Orange County Register she’s not worried about getting bumped up.

“As long as there are people still breathing who think my name is Kathie Lee Gifford — and that happens at least once a week — I’m going to be on the D-list,” Griffin said.